Intranasally administered IGF-1 inhibits spreading depression in vivo
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چکیده
منابع مشابه
In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures.
Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows clinical promise for migraine therapy, although its efficacy and mechanism of action are unclear. As detected by diffusion-weighted MRI (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin incre...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2017
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2017.09.022